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Celecoxib was not mutagenic in an Ames test and a mutation assay in Chinese hamster ovaryCHOcellsnor clastogenic in a chromosome aberration assay in CHO cells and an in vivo micronucleus test in rat bone marrow.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID useThe concurrent use of aspirin and an NSAIDsuch as celecoxibincreases the risk of serious gastrointestinalGIeventssee Gastrointestinal BleedingUlcerationAnd Perforation
Plateletsbleeding or clottingEcchymosisepistaxisthrombocythemiaPsychiatricAnorexiaanxietyappetite increaseddepressionnervousnesssomnolence.
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i have never been rapunsel but i was prescribed celebrex about 18 mos ago.