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Nevirapine plasma levels were not altered by co-administration of tenofovir.
The dose must be strictly adhered toespecially the 14-days lead-in periodsee section 4.2
Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practiceIf there is evidence of worsening liver disease in such patientsinterruption or discontinuation of treatment must be considered.
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patients should be informed to take viramune every day as prescribed.
