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Information about Tegretol.
Aplastic anemia and agranulocytosis have been reported in association with the use of TEGRETOLsee BOXED WARNINGPatients with a history of adverse hematologic reaction to any drug may be particularly at risk of bone marrow depression.
When carbamazepine is added to aripiprazolethe aripiprazole dose should be doubledAdditional dose increases should be based on clinical evaluationIf carbamazepine is later withdrawnthe aripiprazole dose should be reducedWhen carbamazepine is used with tacrolimusmonitoring of tacrolimus blood concentrations and appropriate dosage adjustments are recommendedThe use of concomitant strong CYP3A4 inducers such as carbamazepine should be avoided with temsirolimusIf patients must be coadministered carbamazepine with temsirolimusan adjustment of temsirolimus dosage should be consideredThe use of carbamazepine with lapatinib should generally be avoidedIf carbamazepine is started in a patient already taking lapatinibthe dose of lapatinib should be gradually titrated upIf carbamazepine is discontinuedthe lapatinib dose should be reducedConcomitant use of carbamazepine with nefazodone results in plasma concentrations of nefazodone and its active metabolite insufficient to achieve a therapeutic effectCoadministration of carbamazepine with nefazodone is contraindicatedsee CONTRAINDICATIONSMonitor concentrations of valproate when Tegretol is introduced or withdrawn in patients using valproic acid.
Isolated cases of neuroleptic malignant syndrome have been reported both with and without concomitant use of psychotropic drugs.
Dizzinessdrowsinessdisturbances of coordinationconfusionheadachefatigueblurred visionvisual hallucinationstransient diplopiaoculomotor disturbancesnystagmusspeech disturbancesabnormal involuntary movementsperipheral neuritis and paresthesiasdepression with agitationtalkativenesstinnitushyperacusisneuroleptic malignant syndrome.
Do not stop taking TEGRETOL without first talking to your healthcare provider.
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the mechanism of action of carbamazepine, the active substance of tegretol, has only been partially elucidated.
