Heart or blood pressure medicine such as benazepril lotensin , enalapril vasotec , lisinopril prinivil, zestril , quinapril accupril , ramipril altace , and others;.
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The antihypertensive effect of angiotensin converting enzyme inhibitors is generally lower in black than in non-black patients.
Human DataIt is not known whether exposure limited to the first trimester of pregnancy can adversely affect fetal outcomeThe use of ACE inhibitors during the second and third trimesters of pregnancy has been associated with fetal and neonatal injury including hypotensionneonatal skull hypoplasiaanuriareversible or irreversible renal failureand deathOligohydramnios has also been reportedpresumably resulting from decreased fetal renal functionoligohydramnios in this setting has been associated with fetal limb contracturescraniofacial deformationand hypoplastic lung developmentPrematurity and patent ductus arteriosus have also been reportedalthough it is not clear whether these occurrences were due to the ACE inhibitor exposure.
ACE is identical to kininase IIThuslisinopril may also block the degradation of bradykinina potent vasodilator peptideHoweverthe role that this plays in the therapeutic effects of lisinopril is unknown.
WARNINGThis drug can cause seriouspossibly fatalharm to an unborn baby if used during pregnancyThereforeit is important to prevent pregnancy while taking this medicationConsult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medicationIf you are planning pregnancybecome pregnantor think you may be pregnantcontact your doctor immediately.
Drugs called angiotensin receptor blockersARBssuch as losartanbrand nameCozaarcandesartanAtacandeprosartanTevetenirbesartanAvaprotelmisartanMicardisand valsartanDiovanare commonly used to treat heart failureWe asked whether ARBs reduced deathor severe disability as assessed by hospital admission for any reason versus an inert substanceplaceboor another class of drugs called ACE inhibitorssuch as ramiprilAltacecaptoprilCapotenenalaprilVasotecfosinoprilMonoprillisinoprilPrinivilZestriland quinaprilAccuprilWe also asked whether combining an ARB with an ACE inhibitor is more effective than an ACE inhibitor alone in reducing deathdisabilityor hospital admission for any reasonThe scientific literature was searched to find all trials that had assessed these questions.
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