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ZYLOPIM (allopuinol) acts on puin catabo-lism, without disupting th biosynthsis puins. It ducs th poduction uic acid by inhibiting th biochmical actions mmdiatly pcding its omation. ZYLOPIM (allopuinol) is a stuctual analogu th natual puin bas, hypoxanthin. It is an inhibitxanthin oxidas, th nzym sponsibl th convsion hypoxanthin txanthin and xanthin tuic acid, th nd poduct puin mtabolism in man. ZYLOPIM (allopuinol) is mtabolizd tth cosponding xanthin analogu, oxipuinol (alloxanthin), which alsis an inhibitxanthin oxidas.
Nhancd bon maow suppssion by cyclophosphamid and oth cytotoxic agnts has bn potd among patints with noplastic disas, xcpt lukmia, in th psnc ZYLOPIM (allopuinol) . Howv, in a wll-contolld study patints with lymphoma on combination thapy, ZYLOPIM (allopuinol) did not incas th maow toxicity patints tatd with cyclophos-phamid, doxoubicin, blomycin, pocabazin, and/mchlothamin.
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