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All patients on long-term therapy with this preparation should be questioned and examined periodicallyincluding the testing of knee and ankle reflexesto detect any evidence of muscular weaknessIf weakness occursdiscontinue the drug.
Bullous eruptions including very rare cases of Erythema multiformeStevens-Johnson syndrometoxic epidermal necrolysisphotosensitivityand exfoliative dermatitis have been reported.Not all of the following reactions have been observed with every 4-aminoquinoline compound during long-term therapybut they have been reported with one or more and should be borne in mind when drugs of this class are administeredAdverse effects with different compounds vary in type and frequency.
Retinopathy appears to be dose related and has occurred within several monthsrarelyto several years of daily therapya small number of cases have been reported several years after antimalarial drug therapy was discontinuedIt has not been noted during prolonged use of weekly doses of the 4aminoquinoline compounds for suppression of malaria.
This medication may be available under multiple brand names and/or in several different formsAny specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed hereAs wellsome forms of this medication may not be used for all of the conditions discussed here.
Convulsionsseizuresextrapyramidal symptomsabnormal body movementsrestlessnessshakingor stiffnesssigns of a severe skin reaction such as blisteringpeelinga rash covering a large area of the bodya rash that spreads quicklyor a rash combined with fever or discomfort signs of a serious allergic reactione.gabdominal crampsdifficulty breathingnausea and vomitingor swelling of the face and throatthoughts of suicide or self-harm.
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