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Corticosteroids may exacerbate systemic fungal infections and therefore should not be used in the presence of such infections unless they are needed to control life-threatening drug reactionsThere have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failuresee PRECAUTIONSDrug InteractionsAmphotericin B injection and potassium-depleting agents
Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody responseCorticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccinesRoutine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possiblesee WARNINGSInfectionsVaccination
May lead to inhibition of bone growth in pediatric patients and development of osteoporosis at any agespecial consideration should be given to patients at increased risk of osteoporosise.gpostmenopausal womenbefore initiating corticosteroid therapy.
How are patients typically monitoredPatients will usually have scheduled check-ups with their healthcare provider while they are being treated with dexamethasoneTypicallyblood will be drawn to check levels of blood cells and to monitor functions of some organ systemssuch as the kidneys or liverPatients may undergo physical examinationsscans or other measures to assess side effects and response to therapyPatients may also have their blood sugar levels monitored.
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