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There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogensAdding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasiawhich may be a precursor to endometrial cancerAdequate diagnostic measuresincluding directed or random endometrial sampling when indicatedshould be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding.
If any of these warning signalsor any other unusual symptomshappen while you are using estrogenscall your doctor immediately:
The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.
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