At the time of randomization the patients were in either class iii or iv of congestive heart failure, while maintained on standard therapy an ace inhibitor, loop diuretic with or without digoxin ;.
Information about Digoxin.
Certain serious heart conditionsespeciallyAV blockunless you have a pacemakera recent history of heart attackkidney diseasea thyroid disorderan electrolyte imbalancesuch as low levels of calciumpotassiumor magnesium in your bloodor if you are malnourished or have recently been sick with vomiting or diarrhea.
Other medications can affect the removal of digoxin from your bodywhich may affect how digoxin worksExamples include azole antifungalssuch as itraconazoledronedaronelapatinibmacrolide antibioticssuch as clarithromycinerythromycinpropafenonerifampinStJohn’s wortamong others.
Get emergency medical help if you have signs of an allergic reaction to digoxinhivesdifficulty breathingswelling of your facelipstongueor throat.
Digoxin is generally prescribed in combination with diureticsan ACE inhibitor and a beta-blockerIf you experience an increase in side effects after taking your medications togethercontact your doctorYou may need to change the times you are taking each medicationIf you are taking QuestranQuestran Lightor Colestidtake it at least two hours after digoxin to prevent interactionsConsult with your doctor before taking the following over-the-counter medicationsas they can interfere with the effects of digoxinantacidsasthma remediescoldcough or sinus medicinelaxativesmedicines for diarrheaor diet medicationsFollow your doctor’s dietary advicewhich may includefollowing a low-sodium diettaking a potassium supplementor including high-potassium foodssuch as bananas and orange juicein your diet.
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one study18 demonstrated that compared with placebo, digoxin improved signs and lessened symptoms in patients with heart failure who had normal sinus rhythm and were receiving maintenance diuretic therapy.