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Administration of cilostazol with diltiazema weak inhibitor of CYP3A4resulted in an increase in the AUC of cilostazol of 44accompanied by a 4increase in AUC of the dehydro metabolite and a 43increase in the AUC of the 4trans-hydroxy metabolite.

Read the Patient Information Leaflet if available from your pharmacist before you start taking cilostazol and each time you get a refillIf you have any questionsask your doctor or pharmacist.

In addition to reporting episodes of bleeding and easy bruisingpatients should be warned to promptly report any other signs which might also suggest the early development of blood dyscrasia such as pyrexia and sore throatA full blood count should be performed if infection is suspected or there is any other clinical evidence of blood dyscrasiaCilostazol should be discontinued promptly if there is clinical or laboratory evidence of haematological abnormalities.

The following adverse reactions have been identified during post-approval use of PletalBecause these reactions are reported voluntarily from a population of an unknown sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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